InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BLMH

Summary

InnateDB Protein

IDBP-38899.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BLMH

Protein Name

bleomycin hydrolase

Synonyms

BH; BMH;

Species

Homo sapiens

Ensembl Protein

ENSP00000261714

InnateDB Gene

IDBG-38897 (BLMH)

Protein Structure

UniProt Annotation

Function

The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0004180	carboxypeptidase activity
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006508	proteolysis
GO:0009636	response to toxic substance
GO:0042493	response to drug