Version 5.4
Homo sapiens Gene: BLMH
Summary
InnateDB Gene IDBG-38897.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BLMH
Gene Name bleomycin hydrolase
Synonyms BH; BMH
Species Homo sapiens
Ensembl Gene ENSG00000108578
Encoded Proteins
IDBP-38899
bleomycin hydrolase
IDBP-761907
IDBP-759746
IDBP-757917
IDBP-761065
IDBP-760049
IDBP-759821
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:30248195-30292056
Strand Reverse strand
Band q11.2
Transcripts
ENST00000261714 ENSP00000261714
ENST00000582749
ENST00000580709 ENSP00000466527
ENST00000582669
ENST00000581037 ENSP00000462442
ENST00000579957
ENST00000577290 ENSP00000466948
ENST00000577306
ENST00000578795
ENST00000577623 ENSP00000468681
ENST00000578090 ENSP00000462353
ENST00000579325
ENST00000584603 ENSP00000468486
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0004180 carboxypeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0006508 proteolysis
GO:0009636 response to toxic substance
GO:0042493 response to drug
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020840
View Gene Order
ENSBTAG00000021370
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL K7ESE8
UniProt Splice Variant
Entrez Gene 642
UniGene Hs.371914 Hs.605660 Hs.713465
RefSeq NM_000386
HUGO HGNC:1059
OMIM 602403
CCDS CCDS32604
HPRD 03870
IMGT
EMBL AC087644 AC104984
GenPept
RNA Seq Atlas 642

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca