InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SERPINE2

Summary

InnateDB Protein

IDBP-389139.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SERPINE2

Protein Name

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

Synonyms

GDN; GDNPF; PI-7; PI7; PN-1; PN1; PNI;

Species

Homo sapiens

Ensembl Protein

ENSP00000415786

InnateDB Gene

IDBG-82303 (SERPINE2)

Protein Structure

UniProt Annotation

Function

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005539	glycosaminoglycan binding
GO:0008201	heparin binding

Biological Process

GO:0007596	blood coagulation
GO:0008285	negative regulation of cell proliferation
GO:0009611	response to wounding
GO:0010466	negative regulation of peptidase activity
GO:0010544	negative regulation of platelet activation
GO:0010757	negative regulation of plasminogen activation
GO:0010766	negative regulation of sodium ion transport
GO:0010951	negative regulation of endopeptidase activity
GO:0010955	negative regulation of protein processing
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
GO:0021683	cerebellar granular layer morphogenesis
GO:0030195	negative regulation of blood coagulation
GO:0030308	negative regulation of cell growth
GO:0030334	regulation of cell migration
GO:0032940	secretion by cell
GO:0033363	secretory granule organization
GO:0042177	negative regulation of protein catabolic process
GO:0042628	mating plug formation
GO:0045861	negative regulation of proteolysis
GO:0045879	negative regulation of smoothened signaling pathway
GO:0048505	regulation of timing of cell differentiation
GO:0048711	positive regulation of astrocyte differentiation
GO:0050974	detection of mechanical stimulus involved in sensory perception
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0060291	long-term synaptic potentiation
GO:0060384	innervation
GO:0061108	seminal vesicle epithelium development
GO:0090331	negative regulation of platelet aggregation

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005829	cytosol
GO:0031012	extracellular matrix
GO:0031091	platelet alpha granule
GO:0031232	extrinsic component of external side of plasma membrane
GO:0031594	neuromuscular junction