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InnateDB Protein
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IDBP-389189.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PYHIN1
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Protein Name
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pyrin and HIN domain family, member 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000407616
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InnateDB Gene
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IDBG-103841 (PYHIN1)
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Protein Structure
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| Function |
Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. {ECO:0000269PubMed:16479015, ECO:0000269PubMed:18247378}.
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| Subcellular Localization |
Isoform 1: Nucleus, nucleoplasm.Isoform 3: Nucleus, nucleoplasm.Isoform 5: Nucleus. Nucleus speckle.
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| Disease Associations |
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| Tissue Specificity |
Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors. {ECO:0000269PubMed:15122330}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
2
[view]
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| Protein-Protein |
2
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| PDB ID |
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| InterPro |
IPR004020
DAPIN domain
IPR011029
Death-like domain
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| PFAM |
PF02758
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q6K0P9
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| TrEMBL |
X6RHR0
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| UniProt Splice Variant |
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| Entrez Gene |
149628
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| UniGene |
Hs.734876
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| RefSeq |
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| HUGO |
HGNC:28894
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| OMIM |
612677
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| CCDS |
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| HPRD |
09999
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| IMGT |
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| EMBL |
AL359753
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| GenPept |
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Version 5.4