InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CADM3

Summary

InnateDB Protein

IDBP-389196.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CADM3

Protein Name

cell adhesion molecule 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000387802

InnateDB Gene

IDBG-103868 (CADM3)

Protein Structure

UniProt Annotation

Function

Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized at the cell-cell attached sites of the plasma membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. {ECO:0000269PubMed:11536053, ECO:0000269PubMed:15893517, ECO:0000269PubMed:18420026}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0007156	homophilic cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0045216	cell-cell junction organization

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07679
PF07686
PF08205

PRINTS

PIRSF

SMART

SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8N126