InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPR55

Summary

InnateDB Protein

IDBP-389232.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR55

Protein Name

G protein-coupled receptor 55

Synonyms

LPIR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000410267

InnateDB Gene

IDBG-82998 (GPR55)

Protein Structure

UniProt Annotation

Function

May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L- alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function. {ECO:0000250, ECO:0000269PubMed:19805329}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:18757503}; Multi-pass membrane protein {ECO:0000269PubMed:18757503}.

Disease Associations

Tissue Specificity

Expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. Expressed in osteoclasts and osteoblasts. {ECO:0000269PubMed:19805329, ECO:0000269PubMed:9931487}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004949	cannabinoid receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0035025	positive regulation of Rho protein signal transduction
GO:0038171	cannabinoid signaling pathway
GO:0045453	bone resorption
GO:0045671	negative regulation of osteoclast differentiation
GO:0070374	positive regulation of ERK1 and ERK2 cascade