Version 5.4
Homo sapiens Gene: GPR55
Summary
InnateDB Gene IDBG-82998.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR55
Gene Name G protein-coupled receptor 55
Synonyms LPIR1
Species Homo sapiens
Ensembl Gene ENSG00000135898
Encoded Proteins
IDBP-246469
G protein-coupled receptor 55
IDBP-246471
G protein-coupled receptor 55
IDBP-389232
G protein-coupled receptor 55
IDBP-389233
G protein-coupled receptor 55
IDBP-813761
G protein-coupled receptor 55
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the G protein-coupled receptor (GPR) family, such as GPR55, play important roles in signal transduction from the external environment to the inside of the cell (Sawzdargo et al., 1999 [PubMed 9931487]).[supplied by OMIM, Apr 2008]
This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:230907318-230961066
Strand Reverse strand
Band q37.1
Transcripts
ENST00000392040 ENSP00000375894
ENST00000392039 ENSP00000375893
ENST00000444078 ENSP00000410267
ENST00000438398 ENSP00000412768
ENST00000622008 ENSP00000482381
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004949 cannabinoid receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0035025 positive regulation of Rho protein signal transduction
GO:0038171 cannabinoid signaling pathway
GO:0045453 bone resorption
GO:0045671 negative regulation of osteoclast differentiation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049608
View Gene Order
ENSBTAG00000017431
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9Y2T6
TrEMBL A8K858 C9J1P7
UniProt Splice Variant
Entrez Gene 9290
UniGene Hs.114545
RefSeq NM_005683 XM_005246952
HUGO HGNC:4511
OMIM 604107
CCDS CCDS2480
HPRD 07248
IMGT
EMBL AC012507 AC092534 AF096786 AK292223 BC032694 CH471063 CR541776 FJ348259
GenPept AAD22410 AAH32694 ACI96303 BAF84912 CAG46575 EAW70939 EAW70940
RNA Seq Atlas 9290

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca