InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAPK15

Summary

InnateDB Protein

IDBP-38947.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPK15

Protein Name

mitogen-activated protein kinase 15

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000337691

InnateDB Gene

IDBG-38945 (MAPK15)

Protein Structure

UniProt Annotation

Function

In vitro, phosphorylates MBP. {ECO:0000269PubMed:11875070, ECO:0000269PubMed:16484222}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed with a maximal expression in lung and kidney. {ECO:0000269PubMed:11875070, ECO:0000269PubMed:16484222}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004707	MAP kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017124	SH3 domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0001934	positive regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0008156	negative regulation of DNA replication
GO:0031398	positive regulation of protein ubiquitination
GO:0032355	response to estradiol
GO:0045732	positive regulation of protein catabolic process
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005576	extracellular region
GO:0005622	intracellular
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt