InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WASL

Summary

InnateDB Protein

IDBP-38958.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WASL

Protein Name

Wiskott-Aldrich syndrome-like

Synonyms

N-WASP; NWASP;

Species

Homo sapiens

Ensembl Protein

ENSP00000223023

InnateDB Gene

IDBG-38956 (WASL)

Protein Structure

UniProt Annotation

Function

Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. {ECO:0000269PubMed:19366662, ECO:0000269PubMed:19487689, ECO:0000269PubMed:22847007, ECO:0000269PubMed:22921828}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	71 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0006900	membrane budding
GO:0006928	cellular component movement
GO:0007015	actin filament organization
GO:0007067	mitotic nuclear division
GO:0007411	axon guidance
GO:0008154	actin polymerization or depolymerization
GO:0009617	response to bacterium
GO:0016050	vesicle organization
GO:0030036	actin cytoskeleton organization
GO:0030050	vesicle transport along actin filament
GO:0032880	regulation of protein localization
GO:0034629	cellular protein complex localization
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0046209	nitric oxide metabolic process
GO:0050999	regulation of nitric-oxide synthase activity
GO:0051491	positive regulation of filopodium assembly
GO:0051653	spindle localization
GO:2000370	positive regulation of clathrin-mediated endocytosis

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030027	lamellipodium
GO:0030478	actin cap
GO:0030666	endocytic vesicle membrane
GO:0070062	extracellular vesicular exosome