Homo sapiens Gene: WASL
Summary
InnateDB Gene IDBG-38956.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WASL
Gene Name Wiskott-Aldrich syndrome-like
Synonyms N-WASP; NWASP;
Species Homo sapiens
Ensembl Gene ENSG00000106299
Encoded Proteins
Wiskott-Aldrich syndrome-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:123681935-123749067
Strand Reverse strand
Band q31.32
Transcripts
ENST00000223023 ENSP00000223023
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 73 [view]
Protein-Protein 71 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006461 protein complex assembly
GO:0006900 membrane budding
GO:0006928 cellular component movement
GO:0007015 actin filament organization
GO:0007067 mitotic nuclear division
GO:0007411 axon guidance
GO:0008154 actin polymerization or depolymerization
GO:0009617 response to bacterium
GO:0016050 vesicle organization
GO:0030036 actin cytoskeleton organization
GO:0030050 vesicle transport along actin filament
GO:0032880 regulation of protein localization
GO:0034629 cellular protein complex localization
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0046209 nitric oxide metabolic process
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051491 positive regulation of filopodium assembly
GO:0051653 spindle localization
GO:2000370 positive regulation of clathrin-mediated endocytosis
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030027 lamellipodium
GO:0030478 actin cap
GO:0030666 endocytic vesicle membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
Regulation of actin dynamics for phagocytic cup formation pathway
Developmental Biology pathway
Cell-Cell communication pathway
eNOS activation and regulation pathway
EPHB-mediated forward signaling pathway
Nephrin interactions pathway
Innate Immune System pathway
Metabolism of nitric oxide pathway
Axon guidance pathway
Netrin-1 signaling pathway
Immune System pathway
NOSTRIN mediated eNOS trafficking pathway
DCC mediated attractive signaling pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
EPH-Ephrin signaling pathway
Metabolism pathway
KEGG
Chemokine signaling pathway pathway
Adherens junction pathway
Fc gamma R-mediated phagocytosis pathway
Regulation of actin cytoskeleton pathway
Bacterial invasion of epithelial cells pathway
Pathogenic Escherichia coli infection pathway
Shigellosis pathway
INOH
PID BIOCARTA
Y branching of actin filaments [Biocarta view]
How does salmonella hijack a cell [Biocarta view]
Role of pi3k subunit p85 in regulation of actin organization and cell migration [Biocarta view]
PID NCI
Nephrin/Neph1 signaling in the kidney podocyte
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Netrin-mediated signaling events
ErbB1 downstream signaling
Signaling events mediated by focal adhesion kinase
EPHB forward signaling
CDC42 signaling events
PDGFR-beta signaling pathway
Cross-References
SwissProt O00401
TrEMBL
UniProt Splice Variant
Entrez Gene 8976
UniGene Hs.613761 Hs.731519
RefSeq NM_003941
HUGO HGNC:12735
OMIM 605056
CCDS CCDS34743
HPRD 05448
IMGT
EMBL AC006333 AM295156 BC052955 D88460
GenPept AAH52955 AAQ96857 BAA20128 CAL26602
RNA Seq Atlas 8976