Version 5.4
Homo sapiens Protein: CPD
Summary
InnateDB Protein IDBP-38964.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPD
Protein Name carboxypeptidase D
Synonyms GP180;
Species Homo sapiens
Ensembl Protein ENSP00000225719
InnateDB Gene IDBG-38962 (CPD)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004181 metallocarboxypeptidase activity
GO:0004185 serine-type carboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000834 Peptidase M14, carboxypeptidase A
IPR008969 Carboxypeptidase-like, regulatory domain
PFAM PF00246
PRINTS PR00765
PIRSF
SMART SM00631
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75976
PhosphoSite PhosphoSite-O75976
TrEMBL
UniProt Splice Variant
Entrez Gene 1362
UniGene Hs.608790
RefSeq NP_001295
HUGO HGNC:2301
OMIM 603102
CCDS CCDS11257
HPRD 04375
IMGT
EMBL AC006050 AC090685 AK302497 AK316409 BC045549 BC045624 BC051702 D85390 U65090
GenPept AAC51775 AAH45549 AAH45624 AAH51702 BAA33370 BAH13725 BAH14780

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca