InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRG4

Summary

InnateDB Protein

IDBP-389812.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRG4

Protein Name

proteoglycan 4

Synonyms

bG174L6.2; CACP; HAPO; JCAP; MSF; SZP;

Species

Homo sapiens

Ensembl Protein

ENSP00000399679

InnateDB Gene

IDBG-105398 (PRG4)

Protein Structure

UniProt Annotation

Function

Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.

Subcellular Localization

Secreted {ECO:0000269PubMed:14976050}.

Disease Associations

Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) [MIM:208250]: Autosomal recessive disorder. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure associated with noninflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. {ECO:0000269PubMed:10545950}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in synovial tissue, cartilage and liver and weakly in heart and lung. Isoform B is expressed in kidney, lung, liver, heart and brain. Isoform C and isoform D are widely expressed. {ECO:0000269PubMed:10545950, ECO:0000269PubMed:11124536}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0030247	polysaccharide binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0006955	immune response
GO:0008283	cell proliferation
GO:0042127	regulation of cell proliferation
GO:0045409	negative regulation of interleukin-6 biosynthetic process
GO:0071425	hematopoietic stem cell proliferation