Version 5.4
Homo sapiens Gene: PRG4
Summary
InnateDB Gene IDBG-105398.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRG4
Gene Name proteoglycan 4
Synonyms bG174L6.2; CACP; HAPO; JCAP; MSF; SZP
Species Homo sapiens
Ensembl Gene ENSG00000116690
Encoded Proteins
IDBP-105402
proteoglycan 4
IDBP-105406
proteoglycan 4
IDBP-105408
proteoglycan 4
IDBP-389812
proteoglycan 4
IDBP-592443
proteoglycan 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:186296279-186314562
Strand Forward strand
Band q31.1
Transcripts
ENST00000367485 ENSP00000356455
ENST00000367483 ENSP00000356453
ENST00000367482 ENSP00000356452
ENST00000445192 ENSP00000399679
ENST00000533951 ENSP00000431330
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005044 scavenger receptor activity
GO:0030247 polysaccharide binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0006955 immune response
GO:0008283 cell proliferation
GO:0042127 regulation of cell proliferation
GO:0045409 negative regulation of interleukin-6 biosynthetic process
GO:0071425 hematopoietic stem cell proliferation
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006014
View Gene Order
ENSBTAG00000011932
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 10216
UniGene Hs.647723
RefSeq NM_001127708 NM_001127709 NM_001127710 NM_005807 XM_006711108
HUGO HGNC:9364
OMIM 604283
CCDS CCDS1369 CCDS44287 CCDS44288
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 10216

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca