InnateDB Protein
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IDBP-38994.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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COPE
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Protein Name
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coatomer protein complex, subunit epsilon
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Synonyms
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epsilon-COP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000345674
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InnateDB Gene
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IDBG-38990 (COPE)
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Protein Structure
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Function |
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP- ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
37
[view]
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Protein-Protein |
37
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005198
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structural molecule activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006822
Coatomer, epsilon subunit
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PFAM |
PF04733
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PRINTS |
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PIRSF |
PIRSF016478
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O14579
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PhosphoSite |
PhosphoSite-O14579
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11316
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UniGene |
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RefSeq |
NP_955474
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HUGO |
HGNC:2234
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OMIM |
606942
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CCDS |
CCDS12388
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HPRD |
06089
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IMGT |
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EMBL |
AC002985
AC005197
AJ131182
AJ249366
AK126476
AK315281
AL136928
BC003155
BC007250
BC017285
BM454494
CH471106
CR456886
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GenPept |
AAB81543
AAC24612
AAH03155
AAH07250
AAH17285
BAG37690
BAG54333
CAA10316
CAB55628
CAB66862
CAG33167
EAW84749
EAW84752
EAW84756
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