InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: COPE

Summary

InnateDB Gene

IDBG-38990.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COPE

Gene Name

coatomer protein complex, subunit epsilon

Synonyms

epsilon-COP

Species

Homo sapiens

Ensembl Gene

ENSG00000105669

Encoded Proteins

IDBP-38992

coatomer protein complex, subunit epsilon

IDBP-38994

coatomer protein complex, subunit epsilon

IDBP-38996

coatomer protein complex, subunit epsilon

IDBP-761328

IDBP-762000

IDBP-811606

coatomer protein complex, subunit epsilon

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta\', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:18899514-18919397

Strand

Reverse strand

Band

p13.11

Transcripts

ENST00000262812	ENSP00000262812
ENST00000351079	ENSP00000345674
ENST00000349893	ENSP00000343134
ENST00000600528
ENST00000595984
ENST00000597646
ENST00000593827	ENSP00000471034
ENST00000599964
ENST00000597026
ENST00000600932	ENSP00000469035
ENST00000598969
ENST00000614388	ENSP00000483420

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity

Biological Process

GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0006891	intra-Golgi vesicle-mediated transport
GO:0015031	protein transport
GO:0048205	COPI coating of Golgi vesicle
GO:0061024	membrane organization

Cellular Component

GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0030126	COPI vesicle coat
GO:0030137	COPI-coated vesicle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000055681

View Gene Order

ENSBTAG00000000810

Not yet available

Pathways

NETPATH

REACTOME

REACT_11096

COPI Mediated Transport pathway

REACT_11208

Golgi to ER Retrograde Transport pathway

REACT_11123

Membrane Trafficking pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_007263 NM_199442 NM_199444

HUGO

OMIM

CCDS

CCDS12387 CCDS12388 CCDS12389

HPRD

06089

IMGT

EMBL

GenPept

RNA Seq Atlas