InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL15

Summary

InnateDB Protein

IDBP-39030.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL15

Protein Name

interleukin 15

Synonyms

IL-15;

Species

Homo sapiens

Ensembl Protein

ENSP00000296545

InnateDB Gene

IDBG-39028 (IL15)

Protein Structure

UniProt Annotation

Function

Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

Subcellular Localization

Isoform IL15-S48AA: Secreted.Isoform IL15-S21AA: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.

Disease Associations

Tissue Specificity

Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15- S21AA is preferentially expressed in tissues such as testis and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	10 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005515	protein binding

Biological Process

GO:0001779	natural killer cell differentiation
GO:0001866	NK T cell proliferation
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007568	aging
GO:0008284	positive regulation of cell proliferation
GO:0014732	skeletal muscle atrophy
GO:0030212	hyaluronan metabolic process
GO:0031667	response to nutrient levels
GO:0032740	positive regulation of interleukin-17 production
GO:0032819	positive regulation of natural killer cell proliferation
GO:0032825	positive regulation of natural killer cell differentiation
GO:0034105	positive regulation of tissue remodeling
GO:0042102	positive regulation of T cell proliferation
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045062	extrathymic T cell selection
GO:0045087	innate immune response (InnateDB)
GO:0045580	regulation of T cell differentiation
GO:0048469	cell maturation
GO:0048535	lymph node development
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050691	regulation of defense response to virus by host
GO:0050729	positive regulation of inflammatory response
GO:0050778	positive regulation of immune response
GO:0071305	cellular response to vitamin D

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane