Version 5.4
Homo sapiens Protein: GOSR1
Summary
InnateDB Protein IDBP-39054.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GOSR1
Protein Name golgi SNAP receptor complex member 1
Synonyms GOLIM2; GOS-28; GOS28; GOS28/P28; GS28; P28;
Species Homo sapiens
Ensembl Protein ENSP00000225724
InnateDB Gene IDBG-39052 (GOSR1)
Protein Structure
UniProt Annotation
Function Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. {ECO:0000269PubMed:15215310, ECO:0000269PubMed:21860593}.
Subcellular Localization Golgi apparatus membrane {ECO:0000269PubMed:15215310, ECO:0000269PubMed:15728195, ECO:0000269PubMed:17274796, ECO:0000269PubMed:17337506, ECO:0000269PubMed:21669198}; Single-pass type IV membrane protein {ECO:0000269PubMed:15215310, ECO:0000269PubMed:15728195, ECO:0000269PubMed:17274796, ECO:0000269PubMed:17337506, ECO:0000269PubMed:21669198}. Note=Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005484 SNAP receptor activity
Biological Process
GO:0006891 intra-Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0031201 SNARE complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95249
PhosphoSite PhosphoSite-O95249
TrEMBL Q9BZZ3
UniProt Splice Variant
Entrez Gene 9527
UniGene Hs.639214
RefSeq NP_004862
HUGO HGNC:4430
OMIM 604026
CCDS CCDS11258
HPRD
IMGT
EMBL AC006050 AC011840 AF047438 AF073926 AF229797 BC040471 CH471159
GenPept AAC39889 AAD12945 AAH40471 AAK01856 EAW51229

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca