InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPR37

Summary

InnateDB Protein

IDBP-39114.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR37

Protein Name

G protein-coupled receptor 37 (endothelin receptor type B-like)

Synonyms

EDNRBL; hET(B)R-LP; PAELR;

Species

Homo sapiens

Ensembl Protein

ENSP00000306449

InnateDB Gene

IDBG-39112 (GPR37)

Protein Structure

UniProt Annotation

Function

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade. {ECO:0000269PubMed:11439185, ECO:0000269PubMed:23690594, ECO:0000269PubMed:9526070}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17059562}; Multi-pass membrane protein {ECO:0000269PubMed:17059562}. Endoplasmic reticulum membrane {ECO:0000269PubMed:17059562}; Multi-pass membrane protein {ECO:0000269PubMed:17059562}.

Disease Associations

Tissue Specificity

Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ). {ECO:0000269PubMed:9526070}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0031987	locomotion involved in locomotory behavior
GO:0042416	dopamine biosynthetic process
GO:0045964	positive regulation of dopamine metabolic process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex