InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRLF3

Summary

InnateDB Protein

IDBP-39173.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRLF3

Protein Name

cytokine receptor-like factor 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000318804

InnateDB Gene

IDBG-39171 (CRLF3)

Protein Structure

UniProt Annotation

Function

May play a role in the negative regulation of cell cycle progression. {ECO:0000269PubMed:19427400}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19427400}. Note=The EGFP- and MYC-tagged protein has been shown to be cytoplasmic. {ECO:0000269PubMed:19427400}.

Disease Associations

Tissue Specificity

Expressed in several embryonic and adult tissues, including adult and fetal brain, liver, spleen and pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma (SCC) and in several other cancer types. Also detected in lesion actinic keratosis (AK). {ECO:0000269PubMed:16865251, ECO:0000269PubMed:19427400}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0030308	negative regulation of cell growth
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046427	positive regulation of JAK-STAT cascade
GO:0071158	positive regulation of cell cycle arrest