InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GAB1

Summary

InnateDB Protein

IDBP-39259.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAB1

Protein Name

GRB2-associated binding protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000262995

InnateDB Gene

IDBG-39257 (GAB1)

Protein Structure

UniProt Annotation

Function

Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 92 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	92 [view]
Protein-Protein	91 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0006979	response to oxidative stress
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007257	activation of JUN kinase activity
GO:0007507	heart development
GO:0008283	cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0008544	epidermis development
GO:0030334	regulation of cell migration
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043410	positive regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0060711	labyrinthine layer development
GO:0070102	interleukin-6-mediated signaling pathway