InnateDB Protein
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IDBP-39261.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GAB1
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Protein Name
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GRB2-associated binding protein 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000262994
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InnateDB Gene
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IDBG-39257 (GAB1)
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Protein Structure
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Function |
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 92 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated |
Total |
92
[view]
|
Protein-Protein |
91
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
12 [view]
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Molecular Function |
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Biological Process |
GO:0007173
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epidermal growth factor receptor signaling pathway
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GO:0008283
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cell proliferation
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GO:0008286
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insulin receptor signaling pathway
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GO:0008543
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fibroblast growth factor receptor signaling pathway
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GO:0038095
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Fc-epsilon receptor signaling pathway
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GO:0045087
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innate immune response (InnateDB)
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GO:0048011
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neurotrophin TRK receptor signaling pathway
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GO:0048015
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phosphatidylinositol-mediated signaling
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Cellular Component |
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PDB ID |
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InterPro |
IPR001849
Pleckstrin homology domain
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PFAM |
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
Q13480
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PhosphoSite |
PhosphoSite-Q13480
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TrEMBL |
D6RF42
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UniProt Splice Variant |
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Entrez Gene |
2549
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UniGene |
Hs.80720
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RefSeq |
NP_002030
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HUGO |
HGNC:4066
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OMIM |
604439
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CCDS |
CCDS3759
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HPRD |
05116
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IMGT |
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EMBL |
AC097658
AC104685
AK289767
AK295684
BC064848
CH471056
DQ021880
U43885
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GenPept |
AAC50380
AAH64848
AAY26398
AAY40964
BAF82456
BAH12155
EAX05072
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