InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFAT5

Summary

InnateDB Protein

IDBP-39267.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFAT5

Protein Name

nuclear factor of activated T-cells 5, tonicity-responsive

Synonyms

NF-AT5; NFATL1; NFATZ; OREBP; TONEBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000338806

InnateDB Gene

IDBG-39265 (NFAT5)

Protein Structure

UniProt Annotation

Function

Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes.

Subcellular Localization

Nucleus. Cytoplasm {ECO:0000250}. Note=Nuclear distribution increases under hypertonic conditions. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes. Also expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	11 [view]
Protein-DNA	13 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007588	excretion
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002909 IPT domain
IPR008366 Nuclear factor of activated T cells (NFAT)
IPR008967 p53-like transcription factor, DNA-binding
IPR011539 Rel homology domain
IPR014756 Immunoglobulin E-set

PFAM

PF01833
PF00554

PRINTS

PR01789

PIRSF

SMART

SM00429

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt