Version 5.4
Homo sapiens Gene: NFAT5
Summary
InnateDB Gene IDBG-39265.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFAT5
Gene Name nuclear factor of activated T-cells 5, tonicity-responsive
Synonyms NF-AT5; NFATL1; NFATZ; OREBP; TONEBP
Species Homo sapiens
Ensembl Gene ENSG00000102908
Encoded Proteins
IDBP-39267
nuclear factor of activated T-cells 5, tonicity-responsive
IDBP-39269
nuclear factor of activated T-cells 5, tonicity-responsive
IDBP-242983
nuclear factor of activated T-cells 5, tonicity-responsive
IDBP-379799
nuclear factor of activated T-cells 5, tonicity-responsive
IDBP-748081
IDBP-749749
IDBP-748522
IDBP-753322
IDBP-748712
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20685965
NFAT5 is a transcription factor that is upregulated by hypertonicity. Activated NFAT5 enhances LPS-mediated NFkB activity by complexing with NFkB and kB elements in downstream genes. (Demonstrated in murine model)
PMID 22496647
NFAT5 expression is strongly induced by Mycobacterium tuberculosis, and plays an essential role in stimulating HIV replication in co-infected macrophages.
InnateDB Annotation from Orthologs
Summary
PMID 20685965
[Mus musculus] Nfat5 is a transcription factor that is upregulated by hypertonicity. Activated Nfat5 enhances LPS-mediated NFkB activity by complexing with NFkB and kB elements in downstream genes.
PMID 22496647
[Mus musculus] Nfat5 expression is strongly induced by Mycobacterium tuberculosis, and plays an essential role in stimulating HIV replication in co-infected macrophages. (Demonstrated in human)
Entrez Gene
Summary The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:69565094-69704666
Strand Forward strand
Band q22.1
Transcripts
ENST00000349945 ENSP00000338806
ENST00000354436 ENSP00000346420
ENST00000393742 ENSP00000377343
ENST00000426654 ENSP00000413126
ENST00000563474 ENSP00000462061
ENST00000568832
ENST00000565301 ENSP00000463214
ENST00000562429
ENST00000566899 ENSP00000455628
ENST00000567990 ENSP00000455115
ENST00000567239 ENSP00000457593
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 11 [view]
Protein-DNA 13 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0001816 cytokine production
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007588 excretion
GO:0010628 positive regulation of gene expression
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070884 regulation of calcineurin-NFAT signaling cascade
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003847
View Gene Order
ENSBTAG00000013412
Not yet available
Cross-References
SwissProt O94916
TrEMBL A0A024R734
UniProt Splice Variant
Entrez Gene 10725
UniGene Hs.371987 Hs.605614 Hs.613383 Hs.614121 Hs.645784 Hs.734240
RefSeq NM_173215 NM_001113178 NM_006599 NM_138713 NM_138714 NM_173214 XM_005255777 XM_006721125
HUGO HGNC:7774
OMIM 604708
CCDS CCDS10882 CCDS10881 CCDS45519
HPRD 05272
IMGT
EMBL AB020634 AC009032 AC012321 AF089824 AF134870 AF163836 AF346509 AJ243298 AJ243299 BC131509 BC146765 CH471092 Z97016
GenPept AAD18136 AAD38360 AAD48441 AAI31510 AAI46766 AAK91166 BAA74850 CAB09693 CAC42764 CAC42765 EAW83278 EAW83279 EAW83280 EAW83281
RNA Seq Atlas 10725

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca