InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NDC80

Summary

InnateDB Protein

IDBP-393.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDC80

Protein Name

NDC80 homolog, kinetochore complex component (S. cerevisiae)

Synonyms

HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3;

Species

Homo sapiens

Ensembl Protein

ENSP00000261597

InnateDB Gene

IDBG-391 (NDC80)

Protein Structure

UniProt Annotation

Function

Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. {ECO:0000269PubMed:12351790, ECO:0000269PubMed:14654001, ECO:0000269PubMed:14699129, ECO:0000269PubMed:15062103, ECO:0000269PubMed:15235793, ECO:0000269PubMed:15239953, ECO:0000269PubMed:15548592, ECO:0000269PubMed:16732327, ECO:0000269PubMed:9315664}.

Subcellular Localization

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	61 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000132	establishment of mitotic spindle orientation
GO:0000278	mitotic cell cycle
GO:0007049	cell cycle
GO:0007051	spindle organization
GO:0007052	mitotic spindle organization
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0008608	attachment of spindle microtubules to kinetochore
GO:0016192	vesicle-mediated transport
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000942	condensed nuclear chromosome outer kinetochore
GO:0005634	nucleus
GO:0005829	cytosol
GO:0016020	membrane
GO:0031262	Ndc80 complex