InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ELF5

Summary

InnateDB Protein

IDBP-39327.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELF5

Protein Name

E74-like factor 5 (ets domain transcription factor)

Synonyms

ESE2;

Species

Homo sapiens

Ensembl Protein

ENSP00000311010

InnateDB Gene

IDBG-39323 (ELF5)

Protein Structure

UniProt Annotation

Function

Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. {ECO:0000269PubMed:10506207}.Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters. {ECO:0000269PubMed:10506207}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00237}.

Disease Associations

Tissue Specificity

Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression. {ECO:0000269PubMed:10506207, ECO:0000269PubMed:9840936}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007398	ectoderm development
GO:0008283	cell proliferation
GO:0030154	cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060644	mammary gland epithelial cell differentiation