Version 5.4
Homo sapiens Gene: ELF5
Summary
InnateDB Gene IDBG-39323.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELF5
Gene Name E74-like factor 5 (ets domain transcription factor)
Synonyms ESE2
Species Homo sapiens
Ensembl Gene ENSG00000135374
Encoded Proteins
IDBP-39325
E74-like factor 5 (ets domain transcription factor)
IDBP-39327
E74-like factor 5 (ets domain transcription factor)
IDBP-371188
E74-like factor 5 (ets domain transcription factor)
IDBP-590855
E74-like factor 5 (ets domain transcription factor)
IDBP-812665
E74-like factor 5 (ets domain transcription factor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:34478793-34513805
Strand Reverse strand
Band p13
Transcripts
ENST00000257832 ENSP00000257832
ENST00000312319 ENSP00000311010
ENST00000429939 ENSP00000407589
ENST00000528709
ENST00000532417 ENSP00000436386
ENST00000620316 ENSP00000484521
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007398 ectoderm development
GO:0008283 cell proliferation
GO:0030154 cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060644 mammary gland epithelial cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027186
View Gene Order
ENSBTAG00000012460
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.11713
RefSeq NM_001243080 NM_001243081 NM_001422 NM_198381
HUGO
OMIM
CCDS CCDS58129 CCDS73273 CCDS7892 CCDS7893
HPRD 05525
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca