InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SND1

Summary

InnateDB Protein

IDBP-39511.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SND1

Protein Name

staphylococcal nuclease and tudor domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000346762

InnateDB Gene

IDBG-39509 (SND1)

Protein Structure

UniProt Annotation

Function

Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269PubMed:7651391}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17081065}. Nucleus {ECO:0000269PubMed:17081065}. Melanosome {ECO:0000269PubMed:17081065}. Note=In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:7651391}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	78 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0004518	nuclease activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016032	viral process
GO:0031047	gene silencing by RNA
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0016442	RISC complex
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome
GO:0097433	dense body