InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAB5B

Summary

InnateDB Protein

IDBP-39643.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB5B

Protein Name

RAB5B, member RAS oncogene family

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000353444

InnateDB Gene

IDBG-39641 (RAB5B)

Protein Structure

UniProt Annotation

Function

Protein transport. Probably involved in vesicular traffic (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17081065}; Lipid-anchor {ECO:0000269PubMed:17081065}; Cytoplasmic side {ECO:0000269PubMed:17081065}. Early endosome membrane {ECO:0000269PubMed:17081065}; Lipid-anchor {ECO:0000269PubMed:17081065}. Melanosome {ECO:0000269PubMed:17081065}. Note=Enriched in stage I melanosomes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0030742	GTP-dependent protein binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007032	endosome organization
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0019882	antigen processing and presentation
GO:0030100	regulation of endocytosis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030139	endocytic vesicle
GO:0031901	early endosome membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF04670
PF08477

PRINTS

PR00315
PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt