InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IMPDH1

Summary

InnateDB Protein

IDBP-39669.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IMPDH1

Protein Name

IMP (inosine 5'-monophosphate) dehydrogenase 1

Synonyms

IMPD; IMPD1; LCA11; RP10; sWSS2608;

Species

Homo sapiens

Ensembl Protein

ENSP00000346219

InnateDB Gene

IDBG-39659 (IMPDH1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0003938	IMP dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0018580	nitronate monooxygenase activity
GO:0030554	adenyl nucleotide binding
GO:0046872	metal ion binding

Biological Process

GO:0006144	purine nucleobase metabolic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000262 FMN-dependent dehydrogenase
IPR000644 CBS domain
IPR001093 IMP dehydrogenase/GMP reductase
IPR004136 2-nitropropane dioxygenase, NPD
IPR005990 Inosine-5\'-monophosphate dehydrogenase

PFAM

PF01070
PF00571
PF00478
PF03060

PRINTS

PIRSF

PIRSF000130

SMART

SM00116

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt