InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LIF

Summary

InnateDB Protein

IDBP-3970.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIF

Protein Name

leukemia inhibitory factor (cholinergic differentiation factor)

Synonyms

CDF; DIA; HILDA; MLPLI;

Species

Homo sapiens

Ensembl Protein

ENSP00000249075

InnateDB Gene

IDBG-3968 (LIF)

Protein Structure

UniProt Annotation

Function

LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001135	RNA polymerase II transcription factor recruiting transcription factor activity
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005146	leukemia inhibitory factor receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0001974	blood vessel remodeling
GO:0006366	transcription from RNA polymerase II promoter
GO:0006955	immune response
GO:0007275	multicellular organismal development
GO:0007566	embryo implantation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0019827	stem cell maintenance
GO:0030324	lung development
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0042503	tyrosine phosphorylation of Stat3 protein
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043410	positive regulation of MAPK cascade
GO:0045595	regulation of cell differentiation
GO:0045651	positive regulation of macrophage differentiation
GO:0045835	negative regulation of meiosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046697	decidualization
GO:0046888	negative regulation of hormone secretion
GO:0048286	lung alveolus development
GO:0048644	muscle organ morphogenesis
GO:0048666	neuron development
GO:0048711	positive regulation of astrocyte differentiation
GO:0048861	leukemia inhibitory factor signaling pathway
GO:0048863	stem cell differentiation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0060135	maternal process involved in female pregnancy
GO:0060426	lung vasculature development
GO:0060463	lung lobe morphogenesis
GO:0060707	trophoblast giant cell differentiation
GO:0060708	spongiotrophoblast differentiation
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation
GO:1900182	positive regulation of protein localization to nucleus
GO:1901676	positive regulation of histone H3-K27 acetylation