InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SUOX

Summary

InnateDB Protein

IDBP-39705.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SUOX

Protein Name

sulfite oxidase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000348440

InnateDB Gene

IDBG-39701 (SUOX)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion intermembrane space.

Disease Associations

Isolated sulfite oxidase deficiency (ISOD) [MIM:272300]: Characterized by neurological abnormalities including multicystic leukoencephalopathy with brain atrophy. Patients often suffer from seizures. Often leads to death at an early age. {ECO:0000269PubMed:10519592, ECO:0000269PubMed:12112661, ECO:0000269PubMed:12368985, ECO:0000269PubMed:9428520, ECO:0000269PubMed:9600976}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008482	sulfite oxidase activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0030151	molybdenum ion binding
GO:0043546	molybdopterin cofactor binding
GO:0046872	metal ion binding

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0000098	sulfur amino acid catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070221	sulfide oxidation, using sulfide:quinone oxidoreductase

Cellular Component

GO:0005758	mitochondrial intermembrane space
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000572 Oxidoreductase, molybdopterin-binding domain
IPR001199 Cytochrome b5-like heme/steroid binding domain
IPR005066 Moybdenum cofactor oxidoreductase, dimerisation
IPR008335 Eukaryotic molybdopterin oxidoreductase
IPR014756 Immunoglobulin E-set

PFAM

PF00174
PF00173
PF03404

PRINTS

PR00363
PR00407

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P51687