InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDPR

Summary

InnateDB Protein

IDBP-39708.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDPR

Protein Name

pyruvate dehydrogenase phosphatase regulatory subunit

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000288050

InnateDB Gene

IDBG-39706 (PDPR)

Protein Structure

UniProt Annotation

Function

Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine. {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004047	aminomethyltransferase activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0006090	pyruvate metabolic process
GO:0006546	glycine catabolic process
GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0032259	methylation
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR003953 FAD binding domain
IPR006076 FAD dependent oxidoreductase
IPR006222 Glycine cleavage T-protein, N-terminal
IPR013977 Glycine cleavage T-protein, C-terminal barrel domain
IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal domain

PFAM

PF00890
PF01266
PF01571
PF08669

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8NCN5

PhosphoSite