Version 5.4
Homo sapiens Protein: GATAD2A
Summary
InnateDB Protein IDBP-39713.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GATAD2A
Protein Name GATA zinc finger domain containing 2A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000351552
InnateDB Gene IDBG-39711 (GATAD2A)
Protein Structure
UniProt Annotation
Function Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B. {ECO:0000269PubMed:12183469, ECO:0000269PubMed:16415179}.
Subcellular Localization Nucleus speckle {ECO:0000269PubMed:12183469, ECO:0000269PubMed:16415179}. Note=Speckled nuclear localization requires both CR1 and CR2 regions.
Disease Associations
Tissue Specificity Ubiquitous, both in fetal and adult tissues. {ECO:0000269PubMed:12183469}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0030674 protein binding, bridging
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006306 DNA methylation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0016581 NuRD complex
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR000679 Zinc finger, GATA-type
PFAM PF00320
PRINTS PR00619
PIRSF
SMART SM00401
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86YP4
PhosphoSite PhosphoSite-Q86YP4
TrEMBL V9GYX5
UniProt Splice Variant
Entrez Gene 54815
UniGene Hs.118964
RefSeq
HUGO HGNC:29989
OMIM 614997
CCDS CCDS12402
HPRD 11741
IMGT
EMBL AC003030 AC011448 AC092067 AK000092 AL390164 AY186731 BC011684 BC012902 CH471106
GenPept AAH11684 AAH12902 AAO31797 BAA90939 CAB99095 EAW84819 EAW84820 EAW84823

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca