InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HHIP

Summary

InnateDB Protein

IDBP-39725.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HHIP

Protein Name

hedgehog interacting protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000296575

InnateDB Gene

IDBG-39723 (HHIP)

Protein Structure

UniProt Annotation

Function

Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. {ECO:0000269PubMed:11472839, ECO:0000269PubMed:19561609}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=The last 22 C-terminal amino acids may participate in cell membrane attachment.Isoform 2: Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney. {ECO:0000269PubMed:11435703, ECO:0000269Ref.1}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
GO:0048038	quinone binding
GO:0097108	hedgehog family protein binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0007165	signal transduction
GO:0007224	smoothened signaling pathway
GO:0007405	neuroblast proliferation
GO:0009887	organ morphogenesis
GO:0009953	dorsal/ventral pattern formation
GO:0009968	negative regulation of signal transduction
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway
GO:0045879	negative regulation of smoothened signaling pathway
GO:0048705	skeletal system morphogenesis
GO:0055114	oxidation-reduction process
GO:0060441	epithelial tube branching involved in lung morphogenesis