InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PARP10

Summary

InnateDB Protein

IDBP-39739.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PARP10

Protein Name

poly (ADP-ribose) polymerase family, member 10

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000325618

InnateDB Gene

IDBG-39737 (PARP10)

Protein Structure

UniProt Annotation

Function

May play a role in cell proliferation. May be required for the maintenance of cell cycle progression. {ECO:0000269PubMed:15674325, ECO:0000269PubMed:16455663}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:15674325}. Cytoplasm {ECO:0000269PubMed:15674325}. Note=Shuttles between the nuclear and cytoplasmic compartment. A subpopulation concentrates in the nucleolus during late G1/S phase.

Disease Associations

Tissue Specificity

Highly expressed in spleen and thymus. Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes. Low expression in heart, brain, placenta, lung, skeletal muscle, and colon. {ECO:0000269PubMed:15674325}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003950	NAD+ ADP-ribosyltransferase activity
GO:0005515	protein binding
GO:0070530	K63-linked polyubiquitin binding

Biological Process

GO:0006471	protein ADP-ribosylation
GO:0010629	negative regulation of gene expression
GO:0010847	regulation of chromatin assembly
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0033159	negative regulation of protein import into nucleus, translocation
GO:0045071	negative regulation of viral genome replication
GO:0048147	negative regulation of fibroblast proliferation
GO:0070212	protein poly-ADP-ribosylation
GO:0070213	protein auto-ADP-ribosylation
GO:1900045	negative regulation of protein K63-linked ubiquitination