Version 5.4
Homo sapiens Gene: PARP10
Summary
InnateDB Gene IDBG-39737.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARP10
Gene Name poly (ADP-ribose) polymerase family, member 10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000178685
Encoded Proteins
IDBP-39739
poly (ADP-ribose) polymerase family, member 10
IDBP-39743
poly (ADP-ribose) polymerase family, member 10
IDBP-595761
poly (ADP-ribose) polymerase family, member 10
IDBP-601220
poly (ADP-ribose) polymerase family, member 10
IDBP-594901
poly (ADP-ribose) polymerase family, member 10
IDBP-599885
poly (ADP-ribose) polymerase family, member 10
IDBP-585143
poly (ADP-ribose) polymerase family, member 10
IDBP-600276
poly (ADP-ribose) polymerase family, member 10
IDBP-601349
poly (ADP-ribose) polymerase family, member 10
IDBP-593205
poly (ADP-ribose) polymerase family, member 10
IDBP-593898
poly (ADP-ribose) polymerase family, member 10
IDBP-588144
poly (ADP-ribose) polymerase family, member 10
IDBP-601854
poly (ADP-ribose) polymerase family, member 10
IDBP-599319
poly (ADP-ribose) polymerase family, member 10
IDBP-595007
poly (ADP-ribose) polymerase family, member 10
IDBP-593530
poly (ADP-ribose) polymerase family, member 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:143977153-144012772
Strand Reverse strand
Band q24.3
Transcripts
ENST00000313028 ENSP00000325618
ENST00000313059 ENSP00000314320
ENST00000526007
ENST00000524918 ENSP00000431620
ENST00000525773 ENSP00000434776
ENST00000527262 ENSP00000432733
ENST00000528963
ENST00000533665
ENST00000526985
ENST00000525879 ENSP00000436301
ENST00000528625 ENSP00000431818
ENST00000525486 ENSP00000435793
ENST00000531537 ENSP00000432204
ENST00000529842 ENSP00000436697
ENST00000528914 ENSP00000434005
ENST00000528136 ENSP00000431250
ENST00000529311 ENSP00000434411
ENST00000528580
ENST00000530478 ENSP00000436333
ENST00000532311 ENSP00000435161
ENST00000531707 ENSP00000433990
ENST00000534737
ENST00000532660
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0070530 K63-linked polyubiquitin binding
Biological Process
GO:0006471 protein ADP-ribosylation
GO:0008152 metabolic process
GO:0010629 negative regulation of gene expression
GO:0010847 regulation of chromatin assembly
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033159 negative regulation of protein import into nucleus, translocation
GO:0045071 negative regulation of viral genome replication
GO:0048147 negative regulation of fibroblast proliferation
GO:0070212 protein poly-ADP-ribosylation
GO:0070213 protein auto-ADP-ribosylation
GO:1900045 negative regulation of protein K63-linked ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063268
View Gene Order
ENSBTAG00000009677
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.348609
RefSeq NM_032789 XM_005251081
HUGO
OMIM
CCDS CCDS34960
HPRD 15100
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca