InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IKZF4

Summary

InnateDB Protein

IDBP-39746.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IKZF4

Protein Name

IKAROS family zinc finger 4 (Eos)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000262032

InnateDB Gene

IDBG-39744 (IKZF4)

Protein Structure

UniProt Annotation

Function

DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. {ECO:0000269PubMed:10978333, ECO:0000269PubMed:12015313, ECO:0000269PubMed:12444977}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12444977}.

Disease Associations

Tissue Specificity

Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K- 562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively. {ECO:0000269PubMed:10978333}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter