Version 5.4
Homo sapiens Gene: IKZF4
Summary
InnateDB Gene IDBG-39744.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IKZF4
Gene Name IKAROS family zinc finger 4 (Eos)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000123411
Encoded Proteins
IDBP-39746
IKAROS family zinc finger 4 (Eos)
IDBP-377461
IKAROS family zinc finger 4 (Eos)
IDBP-599924
IKAROS family zinc finger 4 (Eos)
IDBP-595638
IKAROS family zinc finger 4 (Eos)
IDBP-583864
IKAROS family zinc finger 4 (Eos)
IDBP-586345
IKAROS family zinc finger 4 (Eos)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56007659-56038435
Strand Forward strand
Band q13.2
Transcripts
ENST00000262032 ENSP00000262032
ENST00000431367 ENSP00000412101
ENST00000548601
ENST00000550860
ENST00000552689 ENSP00000449168
ENST00000549519
ENST00000551103 ENSP00000449857
ENST00000547167 ENSP00000448419
ENST00000547791 ENSP00000450020
ENST00000547668
ENST00000551701
ENST00000551124
ENST00000547556
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002578
View Gene Order
ENSBTAG00000012636
Not yet available
Cross-References
SwissProt Q9H2S9
TrEMBL F8VPL6 F8VW19 G5E9S4
UniProt Splice Variant
Entrez Gene 64375
UniGene Hs.388622 Hs.553221 Hs.734789
RefSeq NM_022465 XM_005269086 XM_005269087 XM_005269089 XM_005269090 XM_005269091 XM_005269092 XM_005269093 XM_005269096 XM_006719561 XM_006719562
HUGO HGNC:13179
OMIM 606239
CCDS CCDS44917
HPRD
IMGT
EMBL AB058685 AC034102 AF230809 BX647761 CH471054
GenPept AAG39221 BAB47411 EAW96873
RNA Seq Atlas 64375

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca