Version 5.4
Homo sapiens Protein: ITIH4
Summary
InnateDB Protein IDBP-39761.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITIH4
Protein Name inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)
Synonyms GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120; PK120;
Species Homo sapiens
Ensembl Protein ENSP00000266041
InnateDB Gene IDBG-39759 (ITIH4)
Protein Structure
UniProt Annotation
Function Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. {ECO:0000269PubMed:19263524}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Liver specific. {ECO:0000269PubMed:7775381, ECO:0000269PubMed:7805892}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0006953 acute-phase response
GO:0010951 negative regulation of endopeptidase activity
GO:0030212 hyaluronan metabolic process
GO:0034097 response to cytokine
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR002035 von Willebrand factor, type A
IPR010600 Inter-alpha-trypsin inhibitor heavy chain, C-terminal
IPR013694 VIT domain
PFAM PF00092
PF06668
PF08487
PF13757
PRINTS
PIRSF
SMART SM00327
SM00609
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14624
PhosphoSite PhosphoSite-Q14624
TrEMBL
UniProt Splice Variant
Entrez Gene 3700
UniGene Hs.709406
RefSeq NP_002209
HUGO HGNC:6169
OMIM 600564
CCDS CCDS2865
HPRD 02781
IMGT
EMBL AC006254 AC099667 AF119856 AK298412 D38535 D38595 U42015 U42016 U43155 U43156 U43157 U43158 U43159 U43160 U43161 U43162 U43163
GenPept AAD05198 AAF69610 BAA07536 BAA07602 BAH12781

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca