Version 5.4
Homo sapiens Gene: ITIH4
Summary
InnateDB Gene IDBG-39759.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITIH4
Gene Name inter-alpha-trypsin inhibitor heavy chain family, member 4
Synonyms GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120; PK120
Species Homo sapiens
Ensembl Gene ENSG00000055955
Encoded Proteins
IDBP-39761
inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)
IDBP-295645
inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)
IDBP-379777
inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)
IDBP-478958
inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:52812975-52831479
Strand Reverse strand
Band p21.1
Transcripts
ENST00000266041 ENSP00000266041
ENST00000406595 ENSP00000384425
ENST00000441637 ENSP00000395634
ENST00000485816 ENSP00000417824
ENST00000464000
ENST00000491663
ENST00000461966
ENST00000481977
ENST00000471505
ENST00000484632
ENST00000485894
ENST00000467462
ENST00000483372
ENST00000473904
ENST00000537897
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0006953 acute-phase response
GO:0010951 negative regulation of endopeptidase activity
GO:0030212 hyaluronan metabolic process
GO:0034097 response to cytokine
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021922
View Gene Order
ENSBTAG00000007850
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.709406
RefSeq NM_001166449 NM_002218
HUGO
OMIM
CCDS CCDS2865 CCDS54596
HPRD 02781
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca