InnateDB Protein
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IDBP-39773.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ANAPC10
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Protein Name
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anaphase promoting complex subunit 10
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Synonyms
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APC10; DOC1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000310071
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InnateDB Gene
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IDBG-39771 (ANAPC10)
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Protein Structure
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Function |
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269PubMed:18485873}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
52
[view]
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Protein-Protein |
50
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004842
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ubiquitin-protein transferase activity
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Biological Process |
GO:0000086
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G2/M transition of mitotic cell cycle
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GO:0000090
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mitotic anaphase
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GO:0000278
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mitotic cell cycle
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GO:0006511
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ubiquitin-dependent protein catabolic process
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GO:0007067
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mitotic nuclear division
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GO:0007094
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mitotic spindle assembly checkpoint
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GO:0030071
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regulation of mitotic metaphase/anaphase transition
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GO:0031145
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anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
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GO:0051436
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negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051437
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positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051439
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regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0070979
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protein K11-linked ubiquitination
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Cellular Component |
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PDB ID |
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InterPro |
IPR004939
Anaphase-promoting complex, subunit 10/DOC domain
IPR008979
Galactose-binding domain-like
IPR016901
Anaphase-promoting complex, subunit 10
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PFAM |
PF03256
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PRINTS |
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PIRSF |
PIRSF028841
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UM13
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PhosphoSite |
PhosphoSite-Q9UM13
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TrEMBL |
Q4W5I2
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UniProt Splice Variant |
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Entrez Gene |
10393
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UniGene |
Hs.733123
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RefSeq |
NP_055700
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HUGO |
HGNC:24077
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OMIM |
613745
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CCDS |
CCDS43273
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HPRD |
16488
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IMGT |
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EMBL |
AB012109
AC096757
AC097649
AF132794
AL080090
BC005217
CH471056
DQ304649
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GenPept |
AAD30527
AAH05217
AAY40941
ABB96248
BAA86953
CAB45705
EAX05050
EAX05051
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