InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SUZ12

Summary

InnateDB Protein

IDBP-39779.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SUZ12

Protein Name

suppressor of zeste 12 homolog (Drosophila)

Synonyms

CHET9; JJAZ1;

Species

Homo sapiens

Ensembl Protein

ENSP00000316578

InnateDB Gene

IDBG-39777 (SUZ12)

Protein Structure

UniProt Annotation

Function

Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269PubMed:15225548, ECO:0000269PubMed:15231737, ECO:0000269PubMed:15385962, ECO:0000269PubMed:16618801, ECO:0000269PubMed:17344414, ECO:0000269PubMed:18285464}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15231737}.

Disease Associations

Note=A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with JAZF1. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer. {ECO:0000269PubMed:11371647}.

Tissue Specificity

Overexpressed in breast and colon cancer. {ECO:0000269PubMed:15231737, ECO:0000269PubMed:15684044}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 370 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	370 [view]
Protein-Protein	362 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0035064	methylated histone binding
GO:0042054	histone methyltransferase activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0016571	histone methylation
GO:0016574	histone ubiquitination
GO:0045596	negative regulation of cell differentiation