Version 5.4
Homo sapiens Gene: SUZ12
Summary
InnateDB Gene IDBG-39777.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUZ12
Gene Name suppressor of zeste 12 homolog (Drosophila)
Synonyms CHET9; JJAZ1
Species Homo sapiens
Ensembl Gene ENSG00000178691
Encoded Proteins
IDBP-39779
suppressor of zeste 12 homolog (Drosophila)
IDBP-760559
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:31937018-32001045
Strand Forward strand
Band q11.2
Transcripts
ENST00000322652 ENSP00000316578
ENST00000494429
ENST00000580398 ENSP00000463936
ENST00000578106
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 370 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 370 [view]
Protein-Protein 362 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0035064 methylated histone binding
GO:0042054 histone methyltransferase activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
GO:0016571 histone methylation
GO:0016574 histone ubiquitination
GO:0045596 negative regulation of cell differentiation
Cellular Component
GO:0001739 sex chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0035098 ESC/E(Z) complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017548
View Gene Order
ENSBTAG00000018752
Not yet available
Pathways
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_169274
Cellular Senescence pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.462732 Hs.743593
RefSeq NM_015355 XM_005257954 XM_006721794
HUGO
OMIM
CCDS CCDS11270
HPRD 06949
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca