Version 5.4
Homo sapiens Protein: SLC1A2
Summary
InnateDB Protein IDBP-39803.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC1A2
Protein Name solute carrier family 1 (glial high affinity glutamate transporter), member 2
Synonyms EAAT2; GLT-1;
Species Homo sapiens
Ensembl Protein ENSP00000278379
InnateDB Gene IDBG-39801 (SLC1A2)
Protein Structure
UniProt Annotation
Function Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 6 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005313 L-glutamate transmembrane transporter activity
GO:0005515 protein binding
GO:0015501 glutamate:sodium symporter activity
GO:0017153 sodium:dicarboxylate symporter activity
Biological Process
GO:0006811 ion transport
GO:0006835 dicarboxylic acid transport
GO:0007268 synaptic transmission
GO:0007399 nervous system development
GO:0007632 visual behavior
GO:0009416 response to light stimulus
GO:0009611 response to wounding
GO:0010259 multicellular organismal aging
GO:0015813 L-glutamate transport
GO:0021537 telencephalon development
GO:0030534 adult behavior
GO:0031668 cellular response to extracellular stimulus
GO:0035264 multicellular organism growth
GO:0042493 response to drug
GO:0043200 response to amino acid
GO:0046326 positive regulation of glucose import
GO:0051938 L-glutamate import
GO:0055085 transmembrane transport
GO:0070779 D-aspartate import
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030673 axolemma
Protein Structure and Domains
PDB ID
InterPro IPR001991 Sodium:dicarboxylate symporter
PFAM PF00375
PRINTS PR00173
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P43004
PhosphoSite PhosphoSite-P43004
TrEMBL A2A2U1
UniProt Splice Variant
Entrez Gene 6506
UniGene Hs.614269
RefSeq NP_004162
HUGO HGNC:10940
OMIM 600300
CCDS CCDS31459
HPRD 02625
IMGT
EMBL AC090625 AK122843 AK298769 AL133330 AY066021 BC132768 CH471064 D85884 U01824 U03505 Z32517
GenPept AAA18900 AAA50429 AAI32769 AAL57716 BAA28706 BAG53756 BAG60911 CAA83532 CAM28291 EAW68142 EAW68143

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca