InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RHOT1

Summary

InnateDB Protein

IDBP-39868.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RHOT1

Protein Name

ras homolog gene family, member T1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000334724

InnateDB Gene

IDBG-39866 (RHOT1)

Protein Structure

UniProt Annotation

Function

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. {ECO:0000269PubMed:12482879, ECO:0000269PubMed:16630562}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000269PubMed:12482879, ECO:0000269PubMed:19528298}; Single-pass type IV membrane protein {ECO:0000269PubMed:12482879, ECO:0000269PubMed:19528298}. Note=Colocalizes with MGARP and RHOT2 at the mitochondria.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. {ECO:0000269PubMed:12482879}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003924	GTPase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0019725	cellular homeostasis
GO:0047497	mitochondrion transport along microtubule
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097345	mitochondrial outer membrane permeabilization

Cellular Component

GO:0005622	intracellular
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031307	integral component of mitochondrial outer membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR002048 EF-hand domain
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013566 EF hand associated, type-1
IPR013567 EF hand associated, type-2
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR020849 Small GTPase superfamily, Ras type
IPR021181 Small GTPase superfamily, mitochondrial Rho
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM