InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CALU

Summary

InnateDB Protein

IDBP-39929.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CALU

Protein Name

calumenin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000249364

InnateDB Gene

IDBG-39925 (CALU)

Protein Structure

UniProt Annotation

Function

Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum lumen. Secreted. Melanosome. Sarcoplasmic reticulum lumen {ECO:0000250}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	85 [view]
Protein-Protein	84 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0002576	platelet degranulation
GO:0007596	blood coagulation
GO:0008150	biological_process
GO:0030168	platelet activation

Cellular Component

GO:0005576	extracellular region
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0033018	sarcoplasmic reticulum lumen
GO:0042470	melanosome