InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CMA1

Summary

InnateDB Protein

IDBP-3999.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CMA1

Protein Name

chymase 1, mast cell

Synonyms

chymase; CYH; MCT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000250378

InnateDB Gene

IDBG-3997 (CMA1)

Protein Structure

UniProt Annotation

Function

Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.

Subcellular Localization

Secreted. Cytoplasmic granule. Note=Mast cell granules.

Disease Associations

Tissue Specificity

Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions. {ECO:0000269PubMed:8144971}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity
GO:0042277	peptide binding

Biological Process

GO:0002003	angiotensin maturation
GO:0006508	proteolysis
GO:0006518	peptide metabolic process
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030901	midbrain development
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0050720	interleukin-1 beta biosynthetic process
GO:0050727	regulation of inflammatory response
GO:0071333	cellular response to glucose stimulus