InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CMA1

Summary

InnateDB Gene

IDBG-3997.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CMA1

Gene Name

chymase 1, mast cell

Synonyms

chymase; CYH; MCT1

Species

Homo sapiens

Ensembl Gene

ENSG00000092009

Encoded Proteins

IDBP-3999

chymase 1, mast cell

IDBP-4001

chymase 1, mast cell

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24257755

Mast cell chymase CMA1 contributes to the control of inflammation by degrading the virulence factor Hsp70 of Trichinella spiralis, as well as several alarmins such as endogenous HSPA1A, BGN, and HMGB1..

Entrez Gene

Summary

This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:24505353-24508265

Strand

Reverse strand

Band

q12

Transcripts

ENST00000250378	ENSP00000250378
ENST00000206446	ENSP00000206446

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity
GO:0042277	peptide binding

Biological Process

GO:0002003	angiotensin maturation
GO:0006508	proteolysis
GO:0006518	peptide metabolic process
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030901	midbrain development
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0050720	interleukin-1 beta biosynthetic process
GO:0050727	regulation of inflammatory response
GO:0071333	cellular response to glucose stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005622	intracellular
GO:0030141	secretory granule
GO:0031012	extracellular matrix

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000022225

View Gene Order

Pathways

NETPATH

REACTOME

REACT_111040

Signaling by SCF-KIT pathway

REACT_147707

Metabolism of Angiotensinogen to Angiotensins pathway

REACT_118682

Activation of Matrix Metalloproteinases pathway

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

REACT_111102

Signal Transduction pathway

REACT_17015

Metabolism of proteins pathway

REACT_160078

Peptide hormone metabolism pathway

KEGG

hsa04614

Renin-angiotensin system pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.135626

RefSeq

NM_001836

HUGO

OMIM

CCDS

CCDS9630

HPRD

00346

IMGT

EMBL

GenPept

RNA Seq Atlas