InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rph3al

Summary

InnateDB Protein

IDBP-400171.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rph3al

Protein Name

rabphilin 3A-like (without C2 domains)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113869

InnateDB Gene

IDBG-200631 (Rph3al)

Protein Structure

UniProt Annotation

Function

Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Regulates the exocytosis of dense-core vesicles in neuroendocrine cells through interaction with RAB27A. Acts as a potential RAB3B effector protein in epithelial cells. {ECO:0000269PubMed:14722103, ECO:0000269PubMed:15159548}.

Subcellular Localization

Cytoplasm. Cytoplasmic vesicle, secretory vesicle membrane. Note=Recruited to the exocytic secretory vesicles by RAB27A.

Disease Associations

Tissue Specificity

Highly expressed in pancreatic islets. High to moderate expression in adrenal gland, pituitary gland and ovary. {ECO:0000269PubMed:16835753}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017137	Rab GTPase binding
GO:0030274	LIM domain binding
GO:0046872	metal ion binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006887	exocytosis
GO:0017158	regulation of calcium ion-dependent exocytosis
GO:0042493	response to drug
GO:0042593	glucose homeostasis
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway
GO:0050714	positive regulation of protein secretion