Version 5.4
Mus musculus Gene: Rph3al
Summary
InnateDB Gene IDBG-200631.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rph3al
Gene Name rabphilin 3A-like (without C2 domains)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020847
Encoded Proteins
IDBP-200633
rabphilin 3A-like (without C2 domains)
IDBP-200635
rabphilin 3A-like (without C2 domains)
IDBP-264575
rabphilin 3A-like (without C2 domains)
IDBP-400171
rabphilin 3A-like (without C2 domains)
IDBP-537164
rabphilin 3A-like (without C2 domains)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181031:
The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:75830999-75938429
Strand Reverse strand
Band B5
Transcripts
ENSMUST00000066504 ENSMUSP00000064202
ENSMUST00000021208 ENSMUSP00000021208
ENSMUST00000108420 ENSMUSP00000104058
ENSMUST00000121287 ENSMUSP00000113869
ENSMUST00000152035 ENSMUSP00000121304
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
GO:0030274 LIM domain binding
GO:0046872 metal ion binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006887 exocytosis
GO:0017158 regulation of calcium ion-dependent exocytosis
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
GO:0050714 positive regulation of protein secretion
Cellular Component
GO:0005737 cytoplasm
GO:0030141 secretory granule
GO:0030658 transport vesicle membrane
GO:0030667 secretory granule membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000181031
View Gene Order
ENSBTAG00000039819
Not yet available
Cross-References
SwissProt
TrEMBL B7FAU1
UniProt Splice Variant
Entrez Gene 380714
UniGene Mm.425697 Mm.488178
RefSeq NM_001291159 NM_029548 XM_006533637 XM_006533638 XM_006533639 XM_006533640 XM_006533641 XM_006533642
OMIM
CCDS CCDS25058 CCDS70243
HPRD
IMGT
MGI ID MGI:1923492
MGI Symbol Rph3al
EMBL AL645569 AL669897 AL731710
GenPept CAT00721
RNA Seq Atlas 380714

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca